Shared Pathways of IkB Kinase-Induced SCF-Mediated Ubiquitination and Degradation for the NF-kB Precursor p105 and IkBa
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منابع مشابه
Differential IkB Kinase Activation and IkBa Degradation by Interleukin-1b and Tumor Necrosis Factor-a in Human U937 Monocytic Cells EVIDENCE FOR ADDITIONAL REGULATORY STEPS IN kB-DEPENDENT TRANSCRIPTION*
The IkB kinases (IKKs) lie downstream of the NF-kBinducing kinase (NIK) and activate NF-kB by phosphorylation of IkBa. This leads to IkBa degradation and release of NF-kB. In U937 monocytic cells, interleukin (IL)-1b (1 ng/ml) and tumor necrosis factor (TNF)-a; 10 ng/ml) induced kB-dependent transcription equally. However, IKK activity was strongly induced by TNF-a but not by IL-1b. This was co...
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